Detailed information of TA system TA147948

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1884581..1884797
• Replicon: chromosome
• Accession: NZ_CP047802
• Organism: Staphylococcus aureus strain UP_1442

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S67_RS09625
• Protein ID: WP_001802298.1
• Coordinates: 1884693..1884797 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1884581..1884636 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S67_RS09605	1880787..1881452	-	666	WP_001024095.1	SDR family oxidoreductase	-
E3S67_RS09610	1881604..1881924	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S67_RS09615	1881926..1882903	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S67_RS09620	1883169..1884260	+	1092	WP_000495669.1	hypothetical protein	-
-	1884581..1884636	+	56	-	-	Antitoxin
E3S67_RS09625	1884693..1884797	-	105	WP_001802298.1	hypothetical protein	Toxin
E3S67_RS09630	1885477..1885635	+	159	WP_001792784.1	hypothetical protein	-
E3S67_RS09635	1886293..1887150	-	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
E3S67_RS09640	1887218..1888000	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147948 WP_001802298.1 NZ_CP047802:c1884797-1884693 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147948 NZ_CP063380:c360541-360254 [Pectobacterium versatile]
ATGAGCTATAGCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGCTAAAACTCGATAAAGCTATCCAACAGCAATTCGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATCCCTTCGGCAAAGTTACGAGGAATGAAGGACTGCTACAAAATCA
AGCTCCGAGCGTCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGGTTATCGCCGTGGTGGCGGTAGGCAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCAAGTGAGCGAATGAGGTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT147948 NZ_CP047802:1884581-1884636 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin