Detailed information of TA system TA147943

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1713259..1713566
• Replicon: chromosome
• Accession: NZ_CP047802
• Organism: Staphylococcus aureus strain UP_1442

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S67_RS08670
• Protein ID: WP_011447039.1
• Coordinates: 1713390..1713566 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1713259..1713398 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S67_RS08630	1708651..1708911	+	261	WP_001791826.1	hypothetical protein	-
E3S67_RS08635	1708964..1709314	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E3S67_RS08640	1709997..1710446	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
E3S67_RS08645	1710541..1710875	-	335	Protein_1659	SH3 domain-containing protein	-
E3S67_RS08650	1711476..1711967	-	492	WP_000920041.1	staphylokinase	-
E3S67_RS08655	1712157..1712912	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3S67_RS08660	1712924..1713178	-	255	WP_000611512.1	phage holin	-
E3S67_RS08665	1713230..1713337	+	108	WP_001791821.1	hypothetical protein	-
-	1713259..1713398	+	140	NuclAT_0	-	Antitoxin
-	1713259..1713398	+	140	NuclAT_0	-	Antitoxin
-	1713259..1713398	+	140	NuclAT_0	-	Antitoxin
-	1713259..1713398	+	140	NuclAT_0	-	Antitoxin
E3S67_RS08670	1713390..1713566	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3S67_RS08675	1713716..1714012	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3S67_RS08680	1714070..1714357	-	288	WP_001040261.1	hypothetical protein	-
E3S67_RS08685	1714404..1714556	-	153	WP_001153681.1	hypothetical protein	-
E3S67_RS08690	1714546..1718327	-	3782	Protein_1668	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1708964..1759397	50433

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147943 WP_011447039.1 NZ_CP047802:c1713566-1713390 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147943 NZ_CP063371:42291-42596 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATTCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT147943 NZ_CP047802:1713259-1713398 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin