Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2930055..2930478 Replicon chromosome
Accession NZ_CP047801
Organism Staphylococcus aureus strain UP_248

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag E3S70_RS14630 Protein ID WP_001065091.1
Coordinates 2930055..2930306 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag E3S70_RS14635 Protein ID WP_000028422.1
Coordinates 2930296..2930478 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S70_RS14590 2925699..2926619 + 921 WP_000138472.1 recombinase RecT -
E3S70_RS14595 2926700..2927317 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
E3S70_RS14600 2927318..2927788 + 471 WP_000934764.1 single-stranded DNA-binding protein -
E3S70_RS14605 2927818..2928713 + 896 Protein_2836 DnaD domain protein -
E3S70_RS14610 2928720..2928938 + 219 WP_000338531.1 hypothetical protein -
E3S70_RS14615 2928947..2929256 + 310 Protein_2838 RusA family crossover junction endodeoxyribonuclease -
E3S70_RS14620 2929269..2929637 + 369 WP_000101274.1 hypothetical protein -
E3S70_RS14625 2929641..2929883 + 243 WP_000131366.1 hypothetical protein -
E3S70_RS14750 2929898..2930062 + 165 WP_000990744.1 hypothetical protein -
E3S70_RS14630 2930055..2930306 + 252 WP_001065091.1 DUF1024 family protein Toxin
E3S70_RS14635 2930296..2930478 + 183 WP_000028422.1 hypothetical protein Antitoxin
E3S70_RS14640 2930471..2931013 + 543 WP_000185659.1 dUTP pyrophosphatase -
E3S70_RS14645 2931050..2931256 + 207 WP_000195803.1 DUF1381 domain-containing protein -
E3S70_RS14650 2931253..2931639 + 387 WP_000592207.1 hypothetical protein -
E3S70_RS14655 2931636..2931785 + 150 WP_000595265.1 transcriptional activator RinB -
E3S70_RS14660 2931785..2931985 + 201 WP_000265043.1 DUF1514 family protein -
E3S70_RS14665 2932013..2932429 + 417 WP_000590122.1 hypothetical protein -
E3S70_RS14670 2932661..2932960 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / tsst-1 / tsst-1 / hlb 2887190..2932960 45770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T147938 WP_001065091.1 NZ_CP047801:2930055-2930306 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T147938 NZ_CP063369:4525264-4525671 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT147938 WP_000028422.1 NZ_CP047801:2930296-2930478 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT147938 NZ_CP063369:4525017-4525283 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References