Detailed information of TA system TA147933

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2759596..2759874
• Replicon: chromosome
• Accession: NZ_CP047801
• Organism: Staphylococcus aureus strain UP_248

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: E3S70_RS13675
• Protein ID: WP_073392962.1
• Coordinates: 2759596..2759700 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2759696..2759874 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S70_RS13660	2756392..2757174	+	783	WP_000908186.1	ABC transporter ATP-binding protein	-
E3S70_RS13665	2757242..2758099	+	858	WP_000370937.1	Cof-type HAD-IIB family hydrolase	-
E3S70_RS13670	2758758..2758916	-	159	WP_001792784.1	hypothetical protein	-
E3S70_RS13675	2759596..2759700	+	105	WP_073392962.1	hypothetical protein	Toxin
-	2759696..2759874	-	179	-	-	Antitoxin
E3S70_RS13680	2760126..2761772	-	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
E3S70_RS13685	2762060..2763151	-	1092	WP_000495684.1	hypothetical protein	-
E3S70_RS13690	2763417..2764397	-	981	WP_000019741.1	CDF family zinc efflux transporter CzrB	-
E3S70_RS13695	2764399..2764719	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2760126..2761772	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3920.80 Da
• Isoelectric Point: 5.5724

>T147933 WP_073392962.1 NZ_CP047801:2759596-2759700 [Staphylococcus aureus]
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147933 NZ_CP063369:3788300-3788407 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGACCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT147933 NZ_CP047801:c2759874-2759696 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Antitoxin