Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2494352..2494869 Replicon chromosome
Accession NZ_CP047801
Organism Staphylococcus aureus strain UP_248

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3S70_RS12310 Protein ID WP_000251928.1
Coordinates 2494603..2494869 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3S70_RS12305 Protein ID WP_000584497.1
Coordinates 2494352..2494603 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S70_RS12275 2490052..2490771 + 720 WP_000479573.1 amino acid ABC transporter permease -
E3S70_RS12280 2490768..2491499 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3S70_RS12285 2491596..2492846 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3S70_RS12290 2493101..2493463 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S70_RS12295 2493482..2494081 + 600 WP_000162804.1 DsbA family protein -
E3S70_RS12300 2494088..2494188 + 101 Protein_2390 hypothetical protein -
E3S70_RS12305 2494352..2494603 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S70_RS12310 2494603..2494869 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3S70_RS12315 2495162..2496709 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S70_RS12320 2496895..2497362 + 468 WP_000153340.1 SRPBCC domain-containing protein -
E3S70_RS12325 2497448..2497630 + 183 WP_000079140.1 hypothetical protein -
E3S70_RS12330 2497833..2498657 + 825 WP_000594640.1 formate/nitrite transporter family protein -
E3S70_RS12335 2499125..2499661 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T147931 WP_000251928.1 NZ_CP047801:2494603-2494869 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147931 NZ_CP063369:2577649-2577927 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCATCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT147931 WP_000584497.1 NZ_CP047801:2494352-2494603 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT147931 NZ_CP063369:2577386-2577646 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References