Detailed information of TA system TA147929

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2469383..2469567
• Replicon: chromosome
• Accession: NZ_CP047801
• Organism: Staphylococcus aureus strain UP_248

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S70_RS12175
• Protein ID: WP_000482647.1
• Coordinates: 2469383..2469490 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2469507..2469567 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S70_RS12150	2464745..2465251	+	507	WP_160176533.1	GyrI-like domain-containing protein	-
E3S70_RS12155	2465341..2466552	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3S70_RS12160	2466734..2467393	-	660	WP_031880749.1	membrane protein	-
E3S70_RS12165	2467453..2468595	-	1143	WP_001176855.1	glycerate kinase	-
E3S70_RS12170	2468863..2469249	+	387	WP_000779351.1	flippase GtxA	-
E3S70_RS12175	2469383..2469490	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2469507..2469567	-	61	-	-	Antitoxin
E3S70_RS12180	2470138..2471901	+	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
E3S70_RS12185	2471926..2473659	+	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3S70_RS12190	2473890..2474057	+	168	Protein_2368	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147929 WP_000482647.1 NZ_CP047801:2469383-2469490 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147929 NZ_CP063369:1469416-1469523 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147929 NZ_CP047801:c2469567-2469507 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin