Detailed information of TA system TA147923

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 562148..562727
• Replicon: chromosome
• Accession: NZ_CP047801
• Organism: Staphylococcus aureus strain UP_248

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3S70_RS03110
• Protein ID: WP_001025401.1
• Coordinates: 562148..562393 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	562362..562727 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S70_RS03070	558422..559045	+	624	WP_001166482.1	hypothetical protein	-
E3S70_RS03075	559191..559373	-	183	WP_000705240.1	hypothetical protein	-
E3S70_RS03080	559444..560175	-	732	WP_000511090.1	XRE family transcriptional regulator	-
E3S70_RS03085	560327..560539	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
E3S70_RS03090	560587..561030	+	444	WP_000435357.1	hypothetical protein	-
E3S70_RS14695	561045..561194	+	150	WP_000771849.1	hypothetical protein	-
E3S70_RS03095	561235..561447	-	213	WP_000362644.1	hypothetical protein	-
E3S70_RS03100	561517..561714	+	198	WP_001148860.1	hypothetical protein	-
E3S70_RS03105	561701..562081	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
E3S70_RS03110	562148..562393	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3S70_RS03115	562362..562727	-	366	WP_001128433.1	hypothetical protein	Antitoxin
E3S70_RS03120	562782..562997	+	216	WP_001097552.1	hypothetical protein	-
E3S70_RS03125	563022..563285	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
E3S70_RS03130	563298..563459	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3S70_RS03135	563538..563861	+	324	WP_000175000.1	hypothetical protein	-
E3S70_RS03140	563876..564238	+	363	WP_000985986.1	hypothetical protein	-
E3S70_RS03145	564235..565401	+	1167	WP_160176490.1	DUF2800 domain-containing protein	-
E3S70_RS03150	565428..565982	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	gnd	518937..617577	98640

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T147923 WP_001025401.1 NZ_CP047801:562148-562393 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147923 NZ_CP063368:906716-907069 [Staphylococcus delphini]
ATGAAGCGCGGAGACGTCTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTGGTCAT
TATCCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTTGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAATAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT147923 NZ_CP047801:c562727-562362 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin