Detailed information of TA system TA147921

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 221790..221970
• Replicon: chromosome
• Accession: NZ_CP047801
• Organism: Staphylococcus aureus strain UP_248

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S70_RS01415
• Protein ID: WP_001801861.1
• Coordinates: 221875..221970 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	221790..221847 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S70_RS01390	217203..219623	-	2421	WP_031880637.1	polysaccharide lyase 8 family protein	-
E3S70_RS01395	220148..220590	+	443	Protein_243	DUF1433 domain-containing protein	-
E3S70_RS01400	220590..221033	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
E3S70_RS01405	221033..221476	+	444	WP_001037039.1	DUF1433 domain-containing protein	-
E3S70_RS01410	221651..221752	-	102	WP_001791232.1	hypothetical protein	-
-	221790..221847	+	58	-	-	Antitoxin
E3S70_RS01415	221875..221970	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S70_RS01420	222421..222867	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
E3S70_RS01425	223060..223629	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
E3S70_RS01430	223629..224996	+	1368	WP_001093574.1	FRG domain-containing protein	-
E3S70_RS01435	225145..225717	-	573	WP_000414222.1	hypothetical protein	-
E3S70_RS01440	225815..226159	-	345	WP_000627550.1	DUF3969 family protein	-
E3S70_RS01445	226200..226826	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T147921 WP_001801861.1 NZ_CP047801:c221970-221875 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T147921 NZ_CP063368:592252-593025 [Staphylococcus delphini]
ATGGGATTAATAGAATACACAAAAATTGATTTTCAAACGGCACTTGAACGTAATTATAGGGGATTGACTAGAGGAAAAAC
ACCAATAAAAAGACCAATTGCAATTTTATTGGGCGGCCAGAGTGGGGCAGGAAAAACTACAATTCATCGTATTAAGCAAT
CGCATTATAATGGTAATATCATTATTATTGACGGGGATACTTTTCGATTGCAACACCCAAAATTCATTGATATACAAAAG
GAATATGGTAAAAAAAGTGTTGAATATACAAATGAATTTGCAGGACGAATGGTTGAATCACTCATTGAGTTACTAAGCGA
ACAACATTATCATCTGCTCATTGAGGGAACTTTAAGAACTGTCGATGTACCGAGACGAACAGCAGTATCTTTAAAATCCA
AGGGTTATCAAGTTGAATTATCACTTATAGCAACAAAGCCTTATTTATCATACTTGAGTACTTTATTAAGATACGAACAA
AATTATAGTATCTCCCCCAAATATGCACGTGCTACGCCTAAAAAATATCATGATAATATAGTAGGGAATTTGGTGGAAAA
CTTAAACATTTTAGAAAAAGAAAAAATTTTTGACAGAATACAAATATTTAAGCGAGATAAAAGCTGTGTATATGATTCTT
ATAAAAATGGTGAATTAATGGCTTCAGAAAAATTACATGAGTTACTATATGGTGTTTGGGATTTGAAAGAAAAAGAAATG
TTGGAATATTGTGAAAATGAATTGAAAATATTAAGAGAAGCAAAGAGAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT147921 NZ_CP047801:221790-221847 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin