Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 106224..106638 Replicon chromosome
Accession NZ_CP047801
Organism Staphylococcus aureus strain UP_248

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3S70_RS00635 Protein ID WP_001662397.1
Coordinates 106224..106475 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E3S70_RS14680 Protein ID WP_000028424.1
Coordinates 106465..106638 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S70_RS00585 101426..102190 + 765 WP_000240896.1 AP2 domain-containing protein -
E3S70_RS00590 102245..102652 + 408 WP_001816890.1 HNH endonuclease -
E3S70_RS00595 102645..103367 + 723 WP_000031113.1 helix-turn-helix domain-containing protein -
E3S70_RS00600 103377..104156 + 780 WP_031880733.1 ATP-binding protein -
E3S70_RS14675 104150..104311 + 162 WP_000237153.1 hypothetical protein -
E3S70_RS00605 104324..104545 + 222 WP_001123688.1 DUF3269 family protein -
E3S70_RS00610 104555..104980 + 426 WP_031906189.1 adenine methyltransferase -
E3S70_RS00615 104977..105381 + 405 WP_000049780.1 DUF1064 domain-containing protein -
E3S70_RS00620 105386..105571 + 186 WP_001187239.1 DUF3113 family protein -
E3S70_RS00625 105572..105934 + 363 WP_031906188.1 phage protein -
E3S70_RS00630 105935..106183 + 249 WP_031906187.1 phi PVL orf 51-like protein -
E3S70_RS00635 106224..106475 + 252 WP_001662397.1 DUF1024 family protein Toxin
E3S70_RS14680 106465..106638 + 174 WP_000028424.1 hypothetical protein Antitoxin
E3S70_RS00640 106639..106920 + 282 WP_000454994.1 hypothetical protein -
E3S70_RS14685 106921..107079 + 159 WP_000889681.1 hypothetical protein -
E3S70_RS00645 107097..107600 + 504 WP_001662396.1 dUTP diphosphatase -
E3S70_RS00650 107637..107810 + 174 WP_001209216.1 hypothetical protein -
E3S70_RS00655 107827..108063 + 237 WP_000195761.1 DUF1381 domain-containing protein -
E3S70_RS00660 108088..108324 + 237 WP_000483477.1 hypothetical protein -
E3S70_RS00665 108317..108490 + 174 WP_002870008.1 transcriptional activator RinB -
E3S70_RS00670 108491..108637 + 147 WP_000989998.1 hypothetical protein -
E3S70_RS00675 108661..109083 + 423 WP_000162699.1 RinA family phage transcriptional activator -
E3S70_RS00680 109270..109710 + 441 WP_001003272.1 terminase small subunit -
E3S70_RS00685 109697..110974 + 1278 WP_000169944.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 92240..137428 45188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9388.34 Da        Isoelectric Point: 3.9864

>T147919 WP_001662397.1 NZ_CP047801:106224-106475 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEKQE
NEY

Download         Length: 252 bp

>T147919 NZ_CP063367:906723-907076 [Staphylococcus delphini]
ATGAAGCGCGGAGACGTCTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTGGTCAT
TATCCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTTGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAATAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT147919 WP_000028424.1 NZ_CP047801:106465-106638 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT147919 NZ_CP063367:906552-906722 [Staphylococcus delphini]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTATA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References