Detailed information of TA system TA147910

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2664682..2664944
• Replicon: chromosome
• Accession: NZ_CP047800
• Organism: Staphylococcus aureus strain UP_296

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S72_RS13250
• Protein ID: WP_001802298.1
• Coordinates: 2664682..2664786 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2664781..2664944 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S72_RS13235	2661479..2662261	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3S72_RS13240	2662329..2663186	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
E3S72_RS13245	2663844..2664002	-	159	WP_001792784.1	hypothetical protein	-
E3S72_RS13250	2664682..2664786	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2664781..2664944	-	164	-	-	Antitoxin
E3S72_RS13255	2665219..2666310	-	1092	WP_000495669.1	hypothetical protein	-
E3S72_RS13260	2666576..2667553	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3S72_RS13265	2667555..2667875	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S72_RS13270	2668027..2668692	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147910 WP_001802298.1 NZ_CP047800:2664682-2664786 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147910 NZ_CP063362:c441272-440847 [Xanthobacter sp. YN2]
ATGATCCTCGTCGACACGAACGTCATTTCGGAGCCGATGACAAAGGTGCCGGACGCCCGCGTCATCGCATGGATCGACGC
CCAAGCCATCGAAACGCTCTATCTCTCGGCAGTCACCTTGGCCGAGCTGCGTTTCGGCATTGCCGTGCTCCCGGCGGGCA
AGCGCCGGGACAGGCTCCGTGCGCGGCTCGAAGATGAGGTGTTGCCGCTTTTTGCCGATCGCGTGCTGCCGTTCGACCTC
GCCGCCTCCGAAGCCTATGCCCGCCTCATGGCGCAAGCCCGCAAACGGGGCACGGCGATCGGCAAGGCCGACGGCTTCAT
CGCCGCCATCGCGGCATCCCGCAGCCTCGTTGTCGCGACCCGTGACGCCGCACCCTTCGAGACGGCAGGCTTGGCTGTCC
TCAACCCTTGGCAGGCTGCCGGCTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT147910 NZ_CP047800:c2664944-2664781 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin