Detailed information of TA system TA147909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2404750..2405267
• Replicon: chromosome
• Accession: NZ_CP047800
• Organism: Staphylococcus aureus strain UP_296

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: E3S72_RS11910
• Protein ID: WP_000113265.1
• Coordinates: 2405001..2405267 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: E3S72_RS11905
• Protein ID: WP_000584499.1
• Coordinates: 2404750..2405001 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S72_RS11875	2400448..2401167	+	720	WP_000479576.1	amino acid ABC transporter permease	-
E3S72_RS11880	2401164..2401895	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
E3S72_RS11885	2401992..2403242	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
E3S72_RS11890	2403497..2403859	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
E3S72_RS11895	2403878..2404477	+	600	WP_000162810.1	DsbA family protein	-
E3S72_RS11900	2404484..2404585	+	102	Protein_2302	hypothetical protein	-
E3S72_RS11905	2404750..2405001	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3S72_RS11910	2405001..2405267	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
E3S72_RS11915	2405302..2405373	+	72	Protein_2305	hypothetical protein	-
E3S72_RS11920	2405562..2407109	+	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
E3S72_RS11925	2407295..2407762	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
E3S72_RS11930	2407846..2408028	+	183	WP_000230292.1	hypothetical protein	-
E3S72_RS11935	2408245..2409069	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
E3S72_RS11940	2409303..2409839	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T147909 WP_000113265.1 NZ_CP047800:2405001-2405267 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T147909 NZ_CP063361:5777713-5778015 [Massilia violaceinigra]
TTGCGCGCTCCTGTGCCGCATTTACGCTTTTCCACGCGGGCACTTCTCGACCTGAAAAGGTTGCGGGAGTTTTTGCAGCC
GAAAAGTCCTGCGGCAGCCAAGCGCGCTGCGCAGGCGATCGTGAAGTCGTTGCGCGTCTTGAGCCAGCGTCCACGACTTG
GGCGTCCGATACCAAATTTGCCTTTTGGCAACTACGAGTTCGTGATTTCTTATGGAAATGCAGGCTACATCGCCCGTTAC
CGTTTCACTGACGGCGTGGTCACAATTTTGTCGGTGAGGCATCAAAAAGAAGCGTCGCCGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT147909 WP_000584499.1 NZ_CP047800:2404750-2405001 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT147909 NZ_CP063361:5777391-5777675 [Massilia violaceinigra]
ATGTCCGACTTCACTTCGCTGGCGCTTGAACTTGATCGGGAAACACAGCGTCGGCTCAATCGCCTGGCTGAAGCGCGCCA
ACTATCGCCGCATTTGATGATGAATGAGGCGATTGCGCAGTATCTTGAACGCGAGGAAAAGAGCGAAGTATTTCGGCAAG
AAACGCTTGACTCATGGAATGAGTATCAGGCAACCGGGTTACACGTTACTGGTGAGGAAGTCATCGCATGGCTTGAAACG
TGGGGCGAAGAGAACGAGCTACCCGCACCCGAGTGCCACAAGTGA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60