Detailed information of TA system TA147907

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2379588..2379772
• Replicon: chromosome
• Accession: NZ_CP047800
• Organism: Staphylococcus aureus strain UP_296

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S72_RS11775
• Protein ID: WP_000482652.1
• Coordinates: 2379588..2379695 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2379712..2379772 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S72_RS11750	2374950..2375423	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
E3S72_RS11755	2375546..2376757	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S72_RS11760	2376939..2377598	-	660	WP_000831298.1	membrane protein	-
E3S72_RS11765	2377658..2378800	-	1143	WP_001176863.1	glycerate kinase	-
E3S72_RS11770	2379068..2379454	+	387	WP_000779360.1	flippase GtxA	-
E3S72_RS11775	2379588..2379695	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2379712..2379772	-	61	-	-	Antitoxin
E3S72_RS11780	2380398..2382161	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
E3S72_RS11785	2382186..2383919	+	1734	WP_160198900.1	ABC transporter ATP-binding protein/permease	-
E3S72_RS11790	2384150..2384317	+	168	Protein_2280	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-110)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T147907 WP_000482652.1 NZ_CP047800:2379588-2379695 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147907 NZ_CP063360:544297-544647 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAGATT
CGTACGATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147907 NZ_CP047800:c2379772-2379712 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin