Detailed information of TA system TA147905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1737918..1738341
• Replicon: chromosome
• Accession: NZ_CP047800
• Organism: Staphylococcus aureus strain UP_296

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: E3S72_RS08800
• Protein ID: WP_031766094.1
• Coordinates: 1738090..1738341 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E3S72_RS08795
• Protein ID: WP_000028421.1
• Coordinates: 1737918..1738100 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S72_RS08750	1733218..1733508	-	291	WP_000665204.1	VRR-NUC domain-containing protein	-
E3S72_RS08755	1733642..1733746	+	105	WP_015978074.1	hypothetical protein	-
E3S72_RS14140	1733849..1736296	-	2448	WP_031765980.1	virulence-associated E family protein	-
E3S72_RS08765	1736348..1736548	-	201	WP_000265258.1	DUF1514 family protein	-
E3S72_RS08770	1736616..1736768	-	153	WP_031767608.1	transcriptional activator RinB	-
E3S72_RS08775	1736761..1736964	-	204	WP_001072794.1	hypothetical protein	-
E3S72_RS08780	1736961..1737155	-	195	WP_000132920.1	hypothetical protein	-
E3S72_RS08785	1737152..1737358	-	207	WP_000195785.1	DUF1381 domain-containing protein	-
E3S72_RS08790	1737395..1737925	-	531	WP_000185651.1	dUTP pyrophosphatase	-
E3S72_RS08795	1737918..1738100	-	183	WP_000028421.1	hypothetical protein	Antitoxin
E3S72_RS08800	1738090..1738341	-	252	WP_031766094.1	DUF1024 family protein	Toxin
E3S72_RS08805	1738334..1738642	-	309	WP_031895322.1	hypothetical protein	-
E3S72_RS08810	1738639..1738986	-	348	WP_000979209.1	hypothetical protein	-
E3S72_RS08815	1739051..1739299	-	249	WP_111023884.1	phi PVL orf 51-like protein	-
E3S72_RS08820	1739299..1739553	-	255	WP_000111487.1	DUF3310 domain-containing protein	-
E3S72_RS08825	1739553..1739952	-	400	Protein_1691	PVL family protein	-
E3S72_RS08830	1739952..1740137	-	186	WP_001164629.1	DUF3113 family protein	-
E3S72_RS08835	1740150..1742102	-	1953	WP_001796208.1	DNA polymerase	-
E3S72_RS08840	1742171..1742728	-	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1705795..1751009	45214

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9393.31 Da
• Isoelectric Point: 4.0362

>T147905 WP_031766094.1 NZ_CP047800:c1738341-1738090 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T147905 NZ_CP063358:c737082-736738 [Pseudomonas stutzeri]
ATGAAAGCACTATTTGTCGAACTACCGCCCTTTGAGCGCCATCGAGCGGACTACCTGGACGATGAGGCCTTTCGCAGCTT
CCAGCGCCTGCTGATGAAGAACCCGGAAGCCGGCGACGTGATCCAGGGAACCGGCGGCCTACGAAAGATTCGCTTTGCCG
ACGAGCGACGACAGAAAGGCAAGCGCGGCGGCATCCGAGTCATCTACTACTGGTGGTTGGGTGGCGCGCAGTTCTGGCTG
TTTACCCTGTATGGGAAGGACGTCCAGGACGACCTGAACGAGCAGCAGAAGAAATTACTCAAGCAGCTGCTGCAAGCAGA
AATTGATGCGAGGACGACACCATGA

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6683.59 Da
• Isoelectric Point: 4.3791

>AT147905 WP_000028421.1 NZ_CP047800:c1738100-1737918 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Nucleotide

• Length: 183 bp

>AT147905 NZ_CP063358:c736741-736427 [Pseudomonas stutzeri]
ATGAAACGAGACATCTTTGCCGAGCTGGTCGAGGGCTTCGAGGCTTTGGAGGATGAACGCCAAGGCAAGGTGACTCTGCG
CTCGCACAAAGTCCAATTACCCGAACTGTGCGAAGTCAGCTCCGAGGAGCTGGTGGAGATCCGCCAGAAGCTGAACATGT
CACGCCCGGTTTTCGCCATGTATCTGCGCACCAACCCGCGCACCTTGGAAAACTGGGAGCAAGGCAGGGCCAAGCCAAAC
GCCCAGGCGACTACGCTGATTCGCCTGGTGCAAAAGTATCCTGAAACGGTCGAGCACCTTGCAGCCCTTGGCTAA