Detailed information of TA system TA147884

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 218220..218400
• Replicon: chromosome
• Accession: NZ_CP047799
• Organism: Staphylococcus aureus strain UP_322

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S73_RS01405
• Protein ID: WP_001801861.1
• Coordinates: 218305..218400 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	218220..218277 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S73_RS01380	213633..216053	-	2421	WP_160200087.1	polysaccharide lyase 8 family protein	-
E3S73_RS01385	216578..217020	+	443	Protein_240	DUF1433 domain-containing protein	-
E3S73_RS01390	217020..217463	+	444	WP_123089997.1	DUF1433 domain-containing protein	-
E3S73_RS01395	217463..217906	+	444	WP_160200088.1	DUF1433 domain-containing protein	-
E3S73_RS01400	218081..218182	-	102	WP_001791232.1	hypothetical protein	-
-	218220..218277	+	58	-	-	Antitoxin
E3S73_RS01405	218305..218400	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S73_RS01410	218851..219297	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
E3S73_RS01415	219490..220059	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
E3S73_RS01420	220059..221426	+	1368	WP_001093574.1	FRG domain-containing protein	-
E3S73_RS01425	221575..222147	-	573	WP_000414222.1	hypothetical protein	-
E3S73_RS01430	222245..222589	-	345	WP_000627550.1	DUF3969 family protein	-
E3S73_RS01435	222630..223256	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hysA	188462..225815	37353

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T147884 WP_001801861.1 NZ_CP047799:c218400-218305 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T147884 NZ_CP063349:c2431725-2431183 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT147884 NZ_CP047799:218220-218277 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin