Detailed information of TA system TA147875

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2315460..2315644
• Replicon: chromosome
• Accession: NZ_CP047798
• Organism: Staphylococcus aureus strain UP_378

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S75_RS11325
• Protein ID: WP_000482647.1
• Coordinates: 2315460..2315567 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2315584..2315644 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S75_RS11300	2310824..2311297	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
E3S75_RS11305	2311420..2312631	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S75_RS11310	2312811..2313470	-	660	WP_000831298.1	membrane protein	-
E3S75_RS11315	2313530..2314672	-	1143	WP_001176860.1	glycerate kinase	-
E3S75_RS11320	2314940..2315326	+	387	WP_000779354.1	flippase GtxA	-
E3S75_RS11325	2315460..2315567	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2315584..2315644	-	61	-	-	Antitoxin
E3S75_RS11330	2315594..2315761	+	168	WP_000301894.1	hypothetical protein	-
E3S75_RS11335	2316139..2317878	+	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3S75_RS11340	2317927..2319660	+	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3S75_RS11345	2319891..2320058	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147875 WP_000482647.1 NZ_CP047798:2315460-2315567 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147875 NZ_CP063344:3978-4259 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147875 NZ_CP047798:c2315644-2315584 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin