Detailed information of TA system TA147863

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2658977..2659240
• Replicon: chromosome
• Accession: NZ_CP047797
• Organism: Staphylococcus aureus strain UP_426

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S77_RS12960
• Protein ID: WP_001802298.1
• Coordinates: 2658977..2659081 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2659076..2659240 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S77_RS12940	2654386..2655168	+	783	WP_000908193.1	ABC transporter ATP-binding protein	-
E3S77_RS12945	2655236..2656093	+	858	WP_000370936.1	Cof-type HAD-IIB family hydrolase	-
E3S77_RS12950	2657142..2658269	+	1128	WP_047213687.1	SAP domain-containing protein	-
E3S77_RS12955	2658319..2658816	+	498	Protein_2514	recombinase family protein	-
E3S77_RS12960	2658977..2659081	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2659076..2659240	-	165	-	-	Antitoxin
E3S77_RS12965	2659588..2660679	-	1092	WP_047213685.1	hypothetical protein	-
E3S77_RS12970	2660945..2661925	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
E3S77_RS12975	2661927..2662247	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S77_RS12980	2662399..2663064	+	666	WP_001024091.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147863 WP_001802298.1 NZ_CP047797:2658977-2659081 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147863 NZ_CP063341:2690185-2690292 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT147863 NZ_CP047797:c2659240-2659076 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin