Detailed information of TA system TA147861

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2377700..2377884
• Replicon: chromosome
• Accession: NZ_CP047797
• Organism: Staphylococcus aureus strain UP_426

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S77_RS11520
• Protein ID: WP_000482647.1
• Coordinates: 2377700..2377807 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2377824..2377884 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S77_RS11495	2373068..2373541	+	474	WP_000456493.1	GyrI-like domain-containing protein	-
E3S77_RS11500	2373664..2374875	-	1212	WP_001191927.1	multidrug effflux MFS transporter	-
E3S77_RS11505	2375057..2375710	-	654	WP_107399837.1	hypothetical protein	-
E3S77_RS11510	2375770..2376912	-	1143	WP_001176870.1	glycerate kinase	-
E3S77_RS11515	2377180..2377566	+	387	WP_000779353.1	flippase GtxA	-
E3S77_RS11520	2377700..2377807	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2377824..2377884	-	61	-	-	Antitoxin
E3S77_RS11525	2378511..2380274	+	1764	WP_031927727.1	ABC transporter ATP-binding protein/permease	-
E3S77_RS11530	2380299..2382032	+	1734	WP_000486497.1	ABC transporter ATP-binding protein/permease	-
E3S77_RS11535	2382263..2382430	+	168	WP_031927726.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147861 WP_000482647.1 NZ_CP047797:2377700-2377807 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147861 NZ_CP063341:c2486064-2485888 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147861 NZ_CP047797:c2377884-2377824 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin