Detailed information of TA system TA147854

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19381..19719
• Replicon: chromosome
• Accession: NZ_CP047797
• Organism: Staphylococcus aureus strain UP_426

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: E3S77_RS00100
• Protein ID: WP_072357969.1
• Coordinates: 19381..19557 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19545..19719 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S77_RS00080	14547..18332	+	3786	Protein_15	hypothetical protein	-
E3S77_RS00085	18322..18474	+	153	WP_000654329.1	hypothetical protein	-
E3S77_RS00090	18521..18808	+	288	WP_001040255.1	hypothetical protein	-
E3S77_RS00095	18864..19238	+	375	WP_000340977.1	hypothetical protein	-
E3S77_RS00100	19381..19557	+	177	WP_072357969.1	putative holin-like toxin	Toxin
-	19545..19719	-	175	-	-	Antitoxin
E3S77_RS00110	19769..20023	+	255	WP_000611512.1	phage holin	-
E3S77_RS00115	20035..20790	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3S77_RS00120	20981..21472	+	492	WP_000920038.1	staphylokinase	-
E3S77_RS00125	22123..22458	+	336	Protein_24	SH3 domain-containing protein	-
E3S77_RS00130	22969..23319	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3S77_RS00135	23371..23631	-	261	WP_001791826.1	hypothetical protein	-
E3S77_RS00140	23942..24121	-	180	WP_000669791.1	hypothetical protein	-
E3S77_RS00145	24443..24693	-	251	Protein_28	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..23319	23318

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T147854 WP_072357969.1 NZ_CP047797:19381-19557 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147854 NZ_CP063341:1011273-1011608 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT147854 NZ_CP047797:c19719-19545 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin