Detailed information of TA system TA147851

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2833572..2834151
• Replicon: chromosome
• Accession: NZ_CP047796
• Organism: Staphylococcus aureus strain UP_462

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: E3S78_RS13940
• Protein ID: WP_160176231.1
• Coordinates: 2833572..2833817 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2833786..2834151 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S78_RS13900	2829847..2830470	+	624	WP_001166482.1	hypothetical protein	-
E3S78_RS13905	2830616..2830798	-	183	WP_000705240.1	hypothetical protein	-
E3S78_RS13910	2830869..2831600	-	732	WP_000511090.1	XRE family transcriptional regulator	-
E3S78_RS13915	2831751..2831963	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
E3S78_RS13920	2832011..2832454	+	444	WP_160176230.1	hypothetical protein	-
E3S78_RS14150	2832469..2832618	+	150	WP_000771849.1	hypothetical protein	-
E3S78_RS13925	2832659..2832871	-	213	WP_000362644.1	hypothetical protein	-
E3S78_RS13930	2832941..2833138	+	198	WP_001148860.1	hypothetical protein	-
E3S78_RS13935	2833125..2833505	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
E3S78_RS13940	2833572..2833817	+	246	WP_160176231.1	DUF2829 domain-containing protein	Toxin
E3S78_RS13945	2833786..2834151	-	366	WP_001128433.1	hypothetical protein	Antitoxin
E3S78_RS13950	2834206..2834421	+	216	WP_001097552.1	hypothetical protein	-
E3S78_RS13955	2834446..2834709	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
E3S78_RS13960	2834722..2834883	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3S78_RS13965	2834962..2835285	+	324	WP_000175000.1	hypothetical protein	-
E3S78_RS13970	2835300..2835662	+	363	WP_000985986.1	hypothetical protein	-
E3S78_RS13975	2835659..2836825	+	1167	WP_000762534.1	DUF2800 domain-containing protein	-
E3S78_RS13980	2836851..2837405	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2825512..2848474	22962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9469.70 Da
• Isoelectric Point: 5.0174

>T147851 WP_160176231.1 NZ_CP047796:2833572-2833817 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISDSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147851 NZ_CP063341:295248-295775 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT147851 NZ_CP047796:c2834151-2833786 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Antitoxin