Detailed information of TA system TA147849

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2498233..2498413
• Replicon: chromosome
• Accession: NZ_CP047796
• Organism: Staphylococcus aureus strain UP_462

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S78_RS12270
• Protein ID: WP_001801861.1
• Coordinates: 2498318..2498413 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2498233..2498290 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S78_RS12245	2493646..2496066	-	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-
E3S78_RS12250	2496591..2497033	+	443	Protein_2364	DUF1433 domain-containing protein	-
E3S78_RS12255	2497033..2497476	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
E3S78_RS12260	2497476..2497919	+	444	WP_160176219.1	DUF1433 domain-containing protein	-
E3S78_RS12265	2498094..2498195	-	102	WP_001791232.1	hypothetical protein	-
-	2498233..2498290	+	58	-	-	Antitoxin
E3S78_RS12270	2498318..2498413	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S78_RS12275	2498864..2499310	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
E3S78_RS12280	2499503..2500072	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
E3S78_RS12285	2500072..2501439	+	1368	WP_001093574.1	FRG domain-containing protein	-
E3S78_RS12290	2501588..2502160	-	573	WP_000414222.1	hypothetical protein	-
E3S78_RS12295	2502258..2502602	-	345	WP_000627550.1	DUF3969 family protein	-
E3S78_RS12300	2502643..2503269	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T147849 WP_001801861.1 NZ_CP047796:c2498413-2498318 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T147849 NZ_CP063341:198580-198687 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT147849 NZ_CP047796:2498233-2498290 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin