147840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1901680..1902197 Replicon chromosome
Accession NZ_CP047796
Organism Staphylococcus aureus strain UP_462

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3S78_RS08980 Protein ID WP_000251928.1
Coordinates 1901931..1902197 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3S78_RS08975 Protein ID WP_000584497.1
Coordinates 1901680..1901931 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S78_RS08945 1897380..1898099 + 720 WP_160176237.1 amino acid ABC transporter permease -
E3S78_RS08950 1898096..1898827 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3S78_RS08955 1898924..1900174 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3S78_RS08960 1900429..1900791 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S78_RS08965 1900810..1901409 + 600 WP_000162804.1 DsbA family protein -
E3S78_RS08970 1901416..1901516 + 101 Protein_1758 hypothetical protein -
E3S78_RS08975 1901680..1901931 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S78_RS08980 1901931..1902197 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3S78_RS08985 1902490..1904037 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S78_RS08990 1904223..1904690 + 468 WP_000153340.1 SRPBCC domain-containing protein -
E3S78_RS08995 1904776..1904958 + 183 WP_000079140.1 hypothetical protein -
E3S78_RS09000 1905161..1905985 + 825 WP_000594640.1 formate/nitrite transporter family protein -
E3S78_RS09005 1906453..1906989 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T147840 WP_000251928.1 NZ_CP047796:1901931-1902197 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147840 NZ_CP063333:402-782 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT147840 WP_000584497.1 NZ_CP047796:1901680-1901931 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT147840 NZ_CP063333:181-402 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References