Detailed information of TA system TA147838

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1876711..1876895
• Replicon: chromosome
• Accession: NZ_CP047796
• Organism: Staphylococcus aureus strain UP_462

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S78_RS08845
• Protein ID: WP_000482647.1
• Coordinates: 1876711..1876818 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1876835..1876895 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S78_RS08820	1872073..1872546	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
E3S78_RS08825	1872669..1873880	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3S78_RS08830	1874062..1874721	-	660	WP_000831298.1	membrane protein	-
E3S78_RS08835	1874781..1875923	-	1143	WP_001176855.1	glycerate kinase	-
E3S78_RS08840	1876191..1876577	+	387	WP_000779351.1	flippase GtxA	-
E3S78_RS08845	1876711..1876818	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1876835..1876895	-	61	-	-	Antitoxin
E3S78_RS08850	1877466..1879229	+	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
E3S78_RS08855	1879254..1880987	+	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3S78_RS08860	1881218..1881385	+	168	Protein_1736	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147838 WP_000482647.1 NZ_CP047796:1876711-1876818 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147838 NZ_CP063332:3942961-3943359 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147838 NZ_CP047796:c1876895-1876835 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin