Detailed information of TA system TA147831

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2398076..2398260
• Replicon: chromosome
• Accession: NZ_CP047795
• Organism: Staphylococcus aureus strain UP_490

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S79_RS11865
• Protein ID: WP_000482647.1
• Coordinates: 2398153..2398260 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2398076..2398136 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S79_RS11850	2393662..2393829	-	168	WP_031785511.1	hypothetical protein	-
E3S79_RS11855	2394060..2395793	-	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3S79_RS11860	2395842..2397581	-	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
-	2398076..2398136	+	61	-	-	Antitoxin
E3S79_RS11865	2398153..2398260	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S79_RS11870	2398394..2398780	-	387	WP_000779354.1	flippase GtxA	-
E3S79_RS11875	2399048..2400190	+	1143	WP_001176860.1	glycerate kinase	-
E3S79_RS11880	2400250..2400909	+	660	WP_000831298.1	membrane protein	-
E3S79_RS11885	2401089..2402300	+	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S79_RS11890	2402423..2402896	-	474	WP_000456491.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147831 WP_000482647.1 NZ_CP047795:c2398260-2398153 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147831 NZ_CP063332:c2233672-2233358 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147831 NZ_CP047795:2398076-2398136 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin