Detailed information of TA system TA147817

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2684658..2684921
• Replicon: chromosome
• Accession: NZ_CP047794
• Organism: Staphylococcus aureus strain UP_551

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S81_RS13155
• Protein ID: WP_001802298.1
• Coordinates: 2684658..2684762 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2684757..2684921 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S81_RS13135	2680067..2680849	+	783	WP_000908193.1	ABC transporter ATP-binding protein	-
E3S81_RS13140	2680917..2681774	+	858	WP_141226525.1	Cof-type HAD-IIB family hydrolase	-
E3S81_RS13145	2682823..2683950	+	1128	WP_047213687.1	SAP domain-containing protein	-
E3S81_RS13150	2684000..2684497	+	498	Protein_2554	recombinase family protein	-
E3S81_RS13155	2684658..2684762	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2684757..2684921	-	165	-	-	Antitoxin
E3S81_RS13160	2685268..2686359	-	1092	WP_047213685.1	hypothetical protein	-
E3S81_RS13165	2686625..2687605	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
E3S81_RS13170	2687607..2687927	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S81_RS13175	2688079..2688744	+	666	WP_001024091.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147817 WP_001802298.1 NZ_CP047794:2684658-2684762 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147817 NZ_CP063314:1453930-1454235 [Proteus vulgaris]
ATGATCTTTAATCTTGAGTTTGATAAGCGTGCCTTGAAAGAATGGCGGAAACTCGATCAAAGCATTAAAGAACAATTTAA
AAAGAAATTAAAAAAATTACAGGAAAACCCTTATATAGAGTCAGCTCGCTTAAAAGATGATCTCGCGGGTTGCTATAAGA
TTAAATTACGAGCATCTGGTTTTCGATTGGTTTACCAAGTTATTGATTCTGAAGTTGTGATTTTAGTTATTGCTGTTGGT
AAGCGTGAAGAGAGTAAAGCTTATTCATTAGCTGAAGTGAGAATTCAAAAGAACAACATGTATTAG

Antitoxin

Nucleotide

• Length: 165 bp

>AT147817 NZ_CP047794:c2684921-2684757 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin