Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2427422..2427939 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag E3S81_RS11835 Protein ID WP_000113263.1
Coordinates 2427673..2427939 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S81_RS11830 Protein ID WP_000584499.1
Coordinates 2427422..2427673 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS11800 2423121..2423840 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S81_RS11805 2423837..2424568 + 732 WP_000615459.1 amino acid ABC transporter ATP-binding protein -
E3S81_RS11810 2424665..2425915 - 1251 WP_001012216.1 FemA/FemB family glycyltransferase FmhA -
E3S81_RS11815 2426170..2426532 + 363 WP_000819846.1 DUF4467 domain-containing protein -
E3S81_RS11820 2426551..2427150 + 600 WP_000162805.1 DsbA family protein -
E3S81_RS11825 2427157..2427257 + 101 Protein_2298 hypothetical protein -
E3S81_RS11830 2427422..2427673 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S81_RS11835 2427673..2427939 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
E3S81_RS11840 2428232..2429779 + 1548 WP_106459716.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S81_RS11845 2429965..2430432 + 468 WP_000153349.1 SRPBCC domain-containing protein -
E3S81_RS11850 2430519..2430701 + 183 WP_000079140.1 hypothetical protein -
E3S81_RS11855 2430904..2431728 + 825 WP_106459717.1 formate/nitrite transporter family protein -
E3S81_RS11860 2432141..2432677 + 537 WP_106459718.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T147816 WP_000113263.1 NZ_CP047794:2427673-2427939 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147816 NZ_CP063314:c1279249-1278998 [Proteus vulgaris]
ATGAAAACGATAAATTATACAGAAGCAAGACAAAACTTAACTTCAATTATGAATGAAACAATTGATGATAGAGTACCCAT
CATGATCACAAGACAAAAGGGTATTCCATGTGTTCTTTTATCTCTTGATGAATACCAAGCACTAGAAGAGACAGCTTATC
TGTTACGATCTCCAGCGAATGCGCGCCATTTGCTCGATTCAATTGATGAACTGAACCAAGGTAAAGGTATAGAAAAGGAT
ATAACGGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT147816 WP_000584499.1 NZ_CP047794:2427422-2427673 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT147816 NZ_CP063314:c1279001-1278747 [Proteus vulgaris]
ATGAAATTAATTTTTTCTGAACAATCATGGAGTGATTATCTTTATTGGCAACAAATGGACAAGAAAATAATTAAACGCAT
TAACGAACTCATAAAAGATATTAAAAGAACACCGTTTAGCGGAATAGGTAAACCAGAGCCCTTGAAACATAATTTAGCAG
GTTTTTGGTCAAGGCGGATCACTGATGAACATCGCCTTATCTACCGTATTACTGATCCCGCTATAGAAATTGCATCATGT
CGATACCACTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References