Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2402440..2402624 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E3S81_RS11700 Protein ID WP_000482647.1
Coordinates 2402440..2402547 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2402564..2402624 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS11675 2397802..2398275 + 474 WP_000456493.1 GyrI-like domain-containing protein -
E3S81_RS11680 2398398..2399609 - 1212 WP_001191927.1 multidrug effflux MFS transporter -
E3S81_RS11685 2399791..2400450 - 660 WP_031927729.1 membrane protein -
E3S81_RS11690 2400510..2401652 - 1143 WP_001176870.1 glycerate kinase -
E3S81_RS11695 2401920..2402306 + 387 WP_000779353.1 flippase GtxA -
E3S81_RS11700 2402440..2402547 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2402564..2402624 - 61 - - Antitoxin
E3S81_RS11705 2403251..2405014 + 1764 WP_031927727.1 ABC transporter ATP-binding protein/permease -
E3S81_RS11710 2405039..2406772 + 1734 WP_000486497.1 ABC transporter ATP-binding protein/permease -
E3S81_RS11715 2407003..2407170 + 168 WP_031927726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlgB / hlgC / hlgA / hlgA / sbi 2401920..2420627 18707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T147814 WP_000482647.1 NZ_CP047794:2402440-2402547 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T147814 NZ_CP063314:260728-260931 [Proteus vulgaris]
ATGACTAAGACAGACTATCTAATGCGTTTAAGAAAATGCACCTCAATCGAAACATTAGAGCGAGTAATTGAAAAAAATAA
ATACGAACTCTCTGATGATGAGCTGGAGCTATTTTATTCAGCGGCTGATCATCGTTTAGCTGAGCTCACAATGAATAAAC
TCTATGACAAAATTCCAGCATCTGTTTGGAAATTTGTAAGATAA

Antitoxin


Download         Length: 61 bp

>AT147814 NZ_CP047794:c2402624-2402564 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References