Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2357274..2357797 Replicon chromosome
Accession NZ_CP047794
Organism Staphylococcus aureus strain UP_551

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag E3S81_RS11485 Protein ID WP_000074048.1
Coordinates 2357531..2357797 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag E3S81_RS11480 Protein ID WP_000587617.1
Coordinates 2357274..2357531 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S81_RS11460 2352353..2353546 + 1194 WP_000675402.1 MFS transporter -
E3S81_RS11465 2353770..2354519 - 750 WP_000072454.1 CPBP family intramembrane metalloprotease -
E3S81_RS11470 2354714..2356291 + 1578 WP_000971447.1 FMN-binding glutamate synthase family protein -
E3S81_RS11475 2356459..2356914 - 456 WP_000732082.1 DUF1307 domain-containing protein -
E3S81_RS11480 2357274..2357531 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S81_RS11485 2357531..2357797 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
E3S81_RS11490 2358153..2359229 + 1077 WP_001076675.1 M42 family metallopeptidase -
E3S81_RS11495 2359574..2360236 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
E3S81_RS11500 2360229..2361005 + 777 WP_106459679.1 iron export ABC transporter permease subunit FetB -
E3S81_RS11505 2361400..2362587 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T147813 WP_000074048.1 NZ_CP047794:2357531-2357797 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T147813 NZ_CP063310:3052890-3054173 [Eggerthella sp. HF-1101]
ATGATCGCCGCCAACGTTTTCCTGTGGGGCACCCGCATCGGGGCCGTCCAGCAAGAGGACGTCGACGACATCCCCGTTTT
CAACTACGACCCCGATTTCACGCTGAGCGGCATCGAGCTTTCCCCGCTCGAGATGCCCCTGTCCGGCGCCCTCTACTCGT
TTCCCACCCTCAACGGCGAGTCGTTCCACGGCTTGCCCGGCATGCTGGCCGATTCGCTGCCGGACAAATTCGGCAACGCC
CTGCTGGACAGCTATCTGGCCCAACACGGCAGGGACTACCGGAGGCTCAGCGCCGTCGAGCGCTTGCTCTATACCGGCAA
ACGCGGAATGGGCGCCTTGGAGTACGAGCCTTCCTACGACCGGTTCGCCCGCAACGACGACGTCGACATCGACGCGTTGG
TCGGCGTCGCGAACGACGTGCTGAACCGGCGCGAGGGAATGCGCGAAACCATGGACGCCAAGGGCCTCGCCCATTTGGTG
AGCGTGGGAACGTCGGCCGGGGGCGCCCGCGCGAAAGCCGTGATCGCCTGGAACCGAACGACGAACGACGTTCGCTCGGG
GCAGGTAGCAGCCGATCCCGGATACGAGCACTGGCTGATCAAGTTCGACGGCGTCGAGAAGAATAAGGACAAGGGAGATT
CCTACGATCGACCTGCGTACACGCGCATAGAGTTCGCCTACTACACCATGGCGATCGCGGCGGGGCTCGAGATGAGCGCG
TGCGAGCTGTTCGAGGAAAACGGGCGCCGGCATTTCATGACGAGGCGCTTCGATCGGACGGCAGACGGCGGCAAGCTGCA
TATGCAAACCCTCGGCGCCCTCGCCCATTTCGACTTCAACGCTCCGGCGGCGCACAGCTACGAGCAAGCCGCCAGCGTCA
TGCGACGCCTGAATCTCGGCCAGGACAGCCTCGAGCAGCTGTACCTCAGAATGACGTTCAACGTTCTGGCCAGGAACCAG
GACGACCACGTGAAGAACCTGTCGTTTTTGATGGACAGGCGCGGAACATGGAGCCTTGCCCCGGCATACGACGTGACGTA
CGCGAACGATCCGGGCAACAAGTGGCTGTCCCGCCATCAGATGACCGTTGCAGGCAAGGCCGAGAACATAGGGCTGGACG
ACCTGCTCGCTGCGGCGAAGGCCATGGACGTCCCGCGCATCCGCGCCTTGGAGCTGACCGAGCAGGTGAACGGGGCCGTC
CGGGAATGGAGAACTTTCGCGCAGTCGGCCGACGTCCCCGAAGCGGCGTGCGAGGAAATCCAGCGAAACCTGCTGACGCT
GTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT147813 WP_000587617.1 NZ_CP047794:2357274-2357531 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT147813 NZ_CP063310:3052549-3052893 [Eggerthella sp. HF-1101]
ATGAAACTGACCGGCTACGAGAACAACACGGCGGTGCTTTCGGAGCTCGCACAGCGCATCCGCGACCAAAGGCTCGCGCT
CGGGCTCACCCAAGCGGAGCTGGCGAAGAAAAGCGGCGTTTCCTCGCGCACGGTGGCGCGCCTCGAGTCGGGCGACGGCA
TCGCGCTCGACGGCTTTCTCGGCATCTTGCGATCGCTGGGAATCCTTCGCAATATCGACCTGCTGGTTCCCGAATACCGG
ATGGCGCCCACCGAGGCATTCGACGGGCGGCAGAAACGCAAGCGGGCCGCCTCCTCGAAAAGCGCGCAGCCGAACAAGGG
TTGGACGTGGGGTGACGAACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References