147806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2815666..2816089 Replicon chromosome
Accession NZ_CP047793
Organism Staphylococcus aureus strain UP_764

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag E3S87_RS13850 Protein ID WP_001065091.1
Coordinates 2815666..2815917 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag E3S87_RS13855 Protein ID WP_000028422.1
Coordinates 2815907..2816089 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S87_RS13810 2811321..2812241 + 921 WP_000138472.1 recombinase RecT -
E3S87_RS13815 2812322..2812939 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
E3S87_RS13820 2812940..2813410 + 471 WP_000934764.1 single-stranded DNA-binding protein -
E3S87_RS13825 2813440..2814324 + 885 WP_000148316.1 DnaD domain protein -
E3S87_RS13830 2814331..2814549 + 219 WP_000338531.1 hypothetical protein -
E3S87_RS13835 2814558..2814867 + 310 Protein_2679 RusA family crossover junction endodeoxyribonuclease -
E3S87_RS13840 2814880..2815248 + 369 WP_000101274.1 hypothetical protein -
E3S87_RS13845 2815252..2815494 + 243 WP_000131366.1 hypothetical protein -
E3S87_RS13950 2815509..2815673 + 165 WP_000990744.1 hypothetical protein -
E3S87_RS13850 2815666..2815917 + 252 WP_001065091.1 DUF1024 family protein Toxin
E3S87_RS13855 2815907..2816089 + 183 WP_000028422.1 hypothetical protein Antitoxin
E3S87_RS13860 2816082..2816624 + 543 WP_000185659.1 dUTP pyrophosphatase -
E3S87_RS13865 2816661..2816867 + 207 WP_000195803.1 DUF1381 domain-containing protein -
E3S87_RS13870 2816864..2817250 + 387 WP_000592207.1 hypothetical protein -
E3S87_RS13875 2817247..2817396 + 150 WP_000595265.1 transcriptional activator RinB -
E3S87_RS13880 2817396..2817596 + 201 WP_000265043.1 DUF1514 family protein -
E3S87_RS13885 2817624..2818040 + 417 WP_000590122.1 hypothetical protein -
E3S87_RS13890 2818272..2818571 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / tsst-1 / hlb 2775793..2818571 42778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T147806 WP_001065091.1 NZ_CP047793:2815666-2815917 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T147806 NZ_CP063303:901701-902126 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT147806 WP_000028422.1 NZ_CP047793:2815907-2816089 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT147806 NZ_CP063303:901454-901720 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References