Detailed information of TA system TA147785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2160074..2160597
• Replicon: chromosome
• Accession: NZ_CP047792
• Organism: Staphylococcus aureus strain UP_794

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E3S88_RS10840
• Protein ID: WP_124780700.1
• Coordinates: 2160074..2160340 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E3S88_RS10845
• Protein ID: WP_000587622.1
• Coordinates: 2160340..2160597 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S88_RS10820	2155281..2156468	-	1188	WP_124780703.1	MFS transporter	-
E3S88_RS10825	2156864..2157640	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
E3S88_RS10830	2157633..2158295	-	663	WP_000923511.1	ATP-binding cassette domain-containing protein	-
E3S88_RS10835	2158642..2159718	-	1077	WP_124780702.1	M42 family metallopeptidase	-
E3S88_RS10840	2160074..2160340	-	267	WP_124780700.1	Txe/YoeB family addiction module toxin	Toxin
E3S88_RS10845	2160340..2160597	-	258	WP_000587622.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3S88_RS10850	2160956..2161411	+	456	WP_000732090.1	YehR family lipoprotein	-
E3S88_RS10855	2161579..2163156	-	1578	WP_000143500.1	FMN-binding glutamate synthase family protein	-
E3S88_RS10860	2163352..2164101	+	750	WP_124780698.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10668.35 Da
• Isoelectric Point: 10.1384

>T147785 WP_124780700.1 NZ_CP047792:c2160340-2160074 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYAVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T147785 NZ_CP063277:898942-899427 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9814.82 Da
• Isoelectric Point: 4.3304

>AT147785 WP_000587622.1 NZ_CP047792:c2160597-2160340 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT147785 NZ_CP063277:898652-898945 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA