Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2160074..2160597 Replicon chromosome
Accession NZ_CP047792
Organism Staphylococcus aureus strain UP_794

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag E3S88_RS10840 Protein ID WP_124780700.1
Coordinates 2160074..2160340 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag E3S88_RS10845 Protein ID WP_000587622.1
Coordinates 2160340..2160597 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S88_RS10820 2155281..2156468 - 1188 WP_124780703.1 MFS transporter -
E3S88_RS10825 2156864..2157640 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
E3S88_RS10830 2157633..2158295 - 663 WP_000923511.1 ATP-binding cassette domain-containing protein -
E3S88_RS10835 2158642..2159718 - 1077 WP_124780702.1 M42 family metallopeptidase -
E3S88_RS10840 2160074..2160340 - 267 WP_124780700.1 Txe/YoeB family addiction module toxin Toxin
E3S88_RS10845 2160340..2160597 - 258 WP_000587622.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S88_RS10850 2160956..2161411 + 456 WP_000732090.1 YehR family lipoprotein -
E3S88_RS10855 2161579..2163156 - 1578 WP_000143500.1 FMN-binding glutamate synthase family protein -
E3S88_RS10860 2163352..2164101 + 750 WP_124780698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10668.35 Da        Isoelectric Point: 10.1384

>T147785 WP_124780700.1 NZ_CP047792:c2160340-2160074 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYAVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T147785 NZ_CP063277:898942-899427 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9814.82 Da        Isoelectric Point: 4.3304

>AT147785 WP_000587622.1 NZ_CP047792:c2160597-2160340 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT147785 NZ_CP063277:898652-898945 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References