Detailed information of TA system TA147783

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2128789..2128973
• Replicon: chromosome
• Accession: NZ_CP047792
• Organism: Staphylococcus aureus strain UP_794

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S88_RS10695
• Protein ID: WP_000482647.1
• Coordinates: 2128866..2128973 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2128789..2128849 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S88_RS10680	2124338..2124505	-	168	Protein_2051	hypothetical protein	-
E3S88_RS10685	2124736..2126469	-	1734	WP_124780729.1	ABC transporter ATP-binding protein/permease	-
E3S88_RS10690	2126494..2128257	-	1764	WP_124780727.1	ABC transporter ATP-binding protein/permease	-
-	2128789..2128849	+	61	-	-	Antitoxin
E3S88_RS10695	2128866..2128973	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S88_RS10700	2129107..2129493	-	387	WP_000779350.1	flippase GtxA	-
E3S88_RS10705	2129761..2130903	+	1143	WP_001176863.1	glycerate kinase	-
E3S88_RS10710	2130963..2131622	+	660	WP_000831300.1	hypothetical protein	-
E3S88_RS10715	2131806..2133017	+	1212	WP_124780723.1	multidrug effflux MFS transporter	-
E3S88_RS10720	2133140..2133613	-	474	WP_124780721.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147783 WP_000482647.1 NZ_CP047792:c2128973-2128866 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147783 NZ_CP063277:c86374-85991 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147783 NZ_CP047792:2128789-2128849 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin