Detailed information of TA system TA147782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2103455..2103972
• Replicon: chromosome
• Accession: NZ_CP047792
• Organism: Staphylococcus aureus strain UP_794

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E3S88_RS10560
• Protein ID: WP_124780751.1
• Coordinates: 2103455..2103721 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E3S88_RS10565
• Protein ID: WP_000584500.1
• Coordinates: 2103721..2103972 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S88_RS10535	2098660..2099196	-	537	WP_020977539.1	GNAT family N-acetyltransferase	-
E3S88_RS10540	2099666..2100490	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
E3S88_RS10545	2100693..2100875	-	183	WP_000079140.1	hypothetical protein	-
E3S88_RS10550	2100962..2101429	-	468	WP_064129555.1	SRPBCC domain-containing protein	-
E3S88_RS10555	2101615..2103162	-	1548	WP_000727770.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
E3S88_RS10560	2103455..2103721	-	267	WP_124780751.1	Txe/YoeB family addiction module toxin	Toxin
E3S88_RS10565	2103721..2103972	-	252	WP_000584500.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3S88_RS10570	2104135..2104236	-	102	Protein_2029	hypothetical protein	-
E3S88_RS10575	2104243..2104842	-	600	WP_124780749.1	DsbA family protein	-
E3S88_RS10580	2104861..2105220	-	360	WP_031865816.1	DUF4467 domain-containing protein	-
E3S88_RS10585	2105475..2106725	+	1251	WP_124780747.1	FemA/FemB family glycyltransferase FmhA	-
E3S88_RS10590	2106822..2107553	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
E3S88_RS10595	2107550..2108269	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.02 Da
• Isoelectric Point: 10.2789

>T147782 WP_124780751.1 NZ_CP047792:c2103721-2103455 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDNNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T147782 NZ_CP063276:c1258040-1257294 [Bacillus mojavensis]
ATGCTTTTATTCTTTCAAATCATGGTCTGGTGCACTATGGCCGCTTTAGGCTTATACGTATACGCCACATGGCGGTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGAAAAACATGGTATTTGCTGTTTGTTTTGGGCGCCATGATATACTGGA
CATATGATCCCTCTTCCCTGTTCACAAACTGGGAACGGTATGTCATTGTCGCTGTCAGCTTTGCTTTAATTGACGCTTTT
ATCTTTTTGAGCGCTTATGTGAAAAAACTGGCCGGCAGTGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCGATCGGCTGAAAACATACCAATATCTGTTGAAAAACGAACCGATTCATGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGAATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAATCTGACGGCCAGCCTT
TGTCACTATTCGACACAGTCTGATAAAGACCGGTTAACCGAGCACATGGAGGATCCCGCTGACGTGCAAACGAGGCTGGA
TCGAAAGGATGTCTATTACGACCAGTATGGAAAAGTAGTGCTCATTCCCTTTACAATCGAGACACAGAGCTATGTCATCA
AACTGACGTCTGACAGCATTGTAACGGAATTTGATTATTTGCTATTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9419.58 Da
• Isoelectric Point: 4.3407

>AT147782 WP_000584500.1 NZ_CP047792:c2103972-2103721 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Nucleotide

• Length: 252 bp

>AT147782 NZ_CP063276:c1257294-1257124 [Bacillus mojavensis]
ATGGAAAACGCGTTTCAAAACGGATGCCATCCGCGGGCAAAGAAACCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCACACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGATGAGTATAAACGAA
AAAAAGCATGA