Detailed information of TA system TA147779

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1842554..1842817
• Replicon: chromosome
• Accession: NZ_CP047792
• Organism: Staphylococcus aureus strain UP_794

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S88_RS09230
• Protein ID: WP_001802298.1
• Coordinates: 1842713..1842817 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1842554..1842718 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S88_RS09210	1838671..1839336	-	666	WP_001024099.1	SDR family oxidoreductase	-
E3S88_RS09215	1839488..1839808	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S88_RS09220	1839810..1840790	+	981	WP_124779853.1	CDF family zinc efflux transporter CzrB	-
E3S88_RS09225	1841056..1842147	+	1092	WP_124779851.1	transcriptional regulator	-
-	1842554..1842718	+	165	-	-	Antitoxin
E3S88_RS09230	1842713..1842817	-	105	WP_001802298.1	hypothetical protein	Toxin
E3S88_RS09235	1842978..1843470	-	493	Protein_1768	recombinase family protein	-
E3S88_RS09240	1843521..1844027	-	507	Protein_1769	SAP domain-containing protein	-
E3S88_RS09245	1845076..1845933	-	858	WP_072512359.1	Cof-type HAD-IIB family hydrolase	-
E3S88_RS09250	1846001..1846783	-	783	WP_124779849.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147779 WP_001802298.1 NZ_CP047792:c1842817-1842713 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147779 NZ_CP063242:4733603-4733890 [Pectobacterium carotovorum]
ATGAGTTATAGCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGCTAAAACTCGATAAAGCTATCCAACAACAATTCGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTGCGGCAAAGTTACGAGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAACGTCAGGCTTTTGTTTGGTTTATGAGGTTATTGACGACGTATTGGTTATCGCCGTGGTAGCGGTAGGCAAA
CGTGAGCGCAGCGGCGTTTATCATCTGGCGAGTGAGCGAATGAGGTAG

Antitoxin

Nucleotide

• Length: 165 bp

>AT147779 NZ_CP047792:1842554-1842718 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin