Detailed information of TA system TA147774

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1670307..1670614
• Replicon: chromosome
• Accession: NZ_CP047792
• Organism: Staphylococcus aureus strain UP_794

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: E3S88_RS08285
• Protein ID: WP_072357969.1
• Coordinates: 1670438..1670614 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1670307..1670446 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S88_RS08245	1665650..1665910	+	261	WP_001791826.1	hypothetical protein	-
E3S88_RS08250	1665963..1666313	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E3S88_RS08255	1666996..1667445	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
E3S88_RS08260	1667538..1667872	-	335	Protein_1579	SH3 domain-containing protein	-
E3S88_RS08265	1668523..1669014	-	492	WP_000920041.1	staphylokinase	-
E3S88_RS08270	1669205..1669960	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3S88_RS08275	1669972..1670226	-	255	WP_000611512.1	phage holin	-
E3S88_RS08280	1670278..1670385	+	108	WP_031762631.1	hypothetical protein	-
-	1670307..1670446	+	140	NuclAT_0	-	Antitoxin
-	1670307..1670446	+	140	NuclAT_0	-	Antitoxin
-	1670307..1670446	+	140	NuclAT_0	-	Antitoxin
-	1670307..1670446	+	140	NuclAT_0	-	Antitoxin
E3S88_RS08285	1670438..1670614	-	177	WP_072357969.1	putative holin-like toxin	Toxin
E3S88_RS08290	1670757..1671131	-	375	WP_000340977.1	hypothetical protein	-
E3S88_RS08295	1671187..1671474	-	288	WP_001262620.1	hypothetical protein	-
E3S88_RS08300	1671520..1671672	-	153	WP_001000058.1	hypothetical protein	-
E3S88_RS08305	1671665..1675447	-	3783	WP_160194566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1665963..1721418	55455

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T147774 WP_072357969.1 NZ_CP047792:c1670614-1670438 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147774 NZ_CP063242:c4046315-4045902 [Pectobacterium carotovorum]
GTGGCCCAGTGGCGATGTGACCTTCGTGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGCCTATTAGTATT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTACGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGCTGCTGAAGAATGGCGTATTACTGTCATTACAAGCGGTTAACGGTAAAGACAA
GCAACAGCTGTGGTTGGCATCGGACAGCATGGGCGATGATGAATGGCGTCACTTGCGTCAAATTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT147774 NZ_CP047792:1670307-1670446 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin