Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2891053..2891452 Replicon chromosome
Accession NZ_CP047791
Organism Staphylococcus aureus strain UP_818

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3S89_RS14420 Protein ID WP_001065102.1
Coordinates 2891053..2891289 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E3S89_RS14575 Protein ID WP_000028424.1
Coordinates 2891279..2891452 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S89_RS14370 2886295..2886966 + 672 WP_085054053.1 hypothetical protein -
E3S89_RS14565 2886963..2887112 + 150 WP_020808005.1 hypothetical protein -
E3S89_RS14375 2887105..2887386 - 282 WP_000414755.1 hypothetical protein -
E3S89_RS14380 2887452..2888222 + 771 WP_020808006.1 conserved phage C-terminal domain-containing protein -
E3S89_RS14385 2888232..2889011 + 780 WP_160199071.1 ATP-binding protein -
E3S89_RS14570 2889005..2889166 + 162 WP_000237154.1 hypothetical protein -
E3S89_RS14390 2889180..2889401 + 222 WP_001123688.1 DUF3269 family protein -
E3S89_RS14395 2889411..2889836 + 426 WP_000451861.1 phage N-6-adenine-methyltransferase -
E3S89_RS14400 2889833..2890237 + 405 WP_000049780.1 DUF1064 domain-containing protein -
E3S89_RS14405 2890242..2890427 + 186 WP_001187258.1 DUF3113 family protein -
E3S89_RS14410 2890428..2890790 + 363 WP_000536050.1 hypothetical protein -
E3S89_RS14415 2890791..2891039 + 249 WP_001126825.1 phi PVL orf 51-like protein -
E3S89_RS14420 2891053..2891289 + 237 WP_001065102.1 DUF1024 family protein Toxin
E3S89_RS14575 2891279..2891452 + 174 WP_000028424.1 hypothetical protein Antitoxin
E3S89_RS14425 2891453..2891734 + 282 WP_000454994.1 hypothetical protein -
E3S89_RS14580 2891735..2891893 + 159 WP_000889681.1 hypothetical protein -
E3S89_RS14430 2891911..2892468 + 558 WP_001061835.1 dUTP diphosphatase -
E3S89_RS14435 2892505..2892750 + 246 WP_001282074.1 hypothetical protein -
E3S89_RS14440 2892747..2892983 + 237 WP_000195767.1 DUF1381 domain-containing protein -
E3S89_RS14445 2893008..2893244 + 237 WP_000483477.1 hypothetical protein -
E3S89_RS14450 2893237..2893386 + 150 WP_000595238.1 transcriptional activator RinB -
E3S89_RS14455 2893545..2894195 + 651 WP_001005262.1 hypothetical protein -
E3S89_RS14460 2894195..2894395 + 201 WP_000265041.1 DUF1514 family protein -
E3S89_RS14465 2894418..2894879 + 462 WP_002955176.1 hypothetical protein -
E3S89_RS14470 2894994..2895446 + 453 WP_000406186.1 nucleoside triphosphate pyrophosphohydrolase family protein -
E3S89_RS14475 2895453..2895818 + 366 WP_000026170.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 2868186..2895818 27632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-47)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 9275.96 Da        Isoelectric Point: 3.7669

>T147769 WP_001065102.1 NZ_CP047791:2891053-2891289 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEIREAINAQWVEYPEDWASEVLREVRELEYEEEQENEY

Download         Length: 237 bp

>T147769 NZ_CP063242:1118749-1119033 [Pectobacterium carotovorum]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCGCCCGTGCGGGAGCAGTTCAC
CAAAAAGTTGAAAGAGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCCGACTGCTATAAAATCA
AACTTCGTTCCGCTGGCTATCGGCTAGTGTATCAAGTGCTTGAACATGAGATCGTAGTACTGGTTTTAGCTGTGGGAAAA
CGTGAACGCTCAGAAGTTTATAAAACAGCCAAAGACCGACTATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT147769 WP_000028424.1 NZ_CP047791:2891279-2891452 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT147769 NZ_CP063242:1118508-1118759 [Pectobacterium carotovorum]
ATGTCCGTACAACCTATCCTTGCGAATGCAGCCGTGAGTATCAGCGACTTTAAAAAATCGCCCAATGCCGCGCTTAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGCTCACCAATGGCCGTATCTCTGGTTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGATTATCAGGAAGATATCGAACTTGCCAAAATCGCCCGTTCTCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References