Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2263346..2263530 Replicon chromosome
Accession NZ_CP047791
Organism Staphylococcus aureus strain UP_818

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E3S89_RS11545 Protein ID WP_000482647.1
Coordinates 2263423..2263530 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2263346..2263406 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S89_RS11530 2258856..2259023 - 168 Protein_2225 hypothetical protein -
E3S89_RS11535 2259254..2260987 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
E3S89_RS11540 2261012..2262775 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2263346..2263406 + 61 - - Antitoxin
E3S89_RS11545 2263423..2263530 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
E3S89_RS11550 2263664..2264050 - 387 WP_000779351.1 flippase GtxA -
E3S89_RS11555 2264318..2265460 + 1143 WP_001176855.1 glycerate kinase -
E3S89_RS11560 2265520..2266179 + 660 WP_000831298.1 membrane protein -
E3S89_RS11565 2266361..2267572 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
E3S89_RS11570 2267695..2268168 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T147767 WP_000482647.1 NZ_CP047791:c2263530-2263423 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T147767 NZ_CP063242:c200060-199881 [Pectobacterium carotovorum]
ATGGATAGCAGAACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTAAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACCATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 61 bp

>AT147767 NZ_CP047791:2263346-2263406 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References