147766

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2238045..2238562 Replicon chromosome
Accession NZ_CP047791
Organism Staphylococcus aureus strain UP_818

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3S89_RS11410 Protein ID WP_000251928.1
Coordinates 2238045..2238311 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3S89_RS11415 Protein ID WP_000584497.1
Coordinates 2238311..2238562 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S89_RS11385 2233253..2233789 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
E3S89_RS11390 2234257..2235081 - 825 WP_000594640.1 formate/nitrite transporter family protein -
E3S89_RS11395 2235284..2235466 - 183 WP_000079140.1 hypothetical protein -
E3S89_RS11400 2235552..2236019 - 468 WP_000153340.1 SRPBCC domain-containing protein -
E3S89_RS11405 2236205..2237752 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S89_RS11410 2238045..2238311 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3S89_RS11415 2238311..2238562 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S89_RS11420 2238726..2238826 - 101 Protein_2203 hypothetical protein -
E3S89_RS11425 2238833..2239432 - 600 WP_000162804.1 DsbA family protein -
E3S89_RS11430 2239451..2239813 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S89_RS11435 2240068..2241318 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3S89_RS11440 2241415..2242146 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3S89_RS11445 2242143..2242862 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T147766 WP_000251928.1 NZ_CP047791:c2238311-2238045 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147766 NZ_CP063241:4690495-4691814 [Pectobacterium brasiliense]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGAATTCTGACCAAGACGGGCAGTGGGGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGATTGCCGAGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGCCCTATCAAG
GCGATGAAGTTTATAACTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGCATCAC
ACGGATTCCACTCAGCCGTTTGATCTGCTCGCTAAAGTGGGGCGAGACAGTGTCGGGGCGTTGCAATTAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATACAAAACCTTATCCGGGCAGCAGCTTGAAAACATACTGACCGGATATC
TGTCTGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATCTCTATCGCAGGTGCACAGGAAAAGACGGCG
TTGCTGTATCTAGATGATCGCTGGTGCCTGCCTCTCAATGCCACACCAACTACCCATATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCATTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGTTTGCTCATTGCCAAGGCAT
TTGGGTTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGTTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAACCTGAGGGGCGATATCGACTCACGCCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGAC
ATTTTTTCCAGACGGCGAAGGTAGTTGGGTTTGCCAGAGAATCGATGGAAAACATTCTGGCGGAGTTTGCCCACACCGTT
GATACCATCATGGCGACTGTTGGAAGTCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT147766 WP_000584497.1 NZ_CP047791:c2238562-2238311 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT147766 NZ_CP063241:4690226-4690495 [Pectobacterium brasiliense]
ATGATGAAGATCACCAACAGCAAGCAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAA
AGTGGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGTTTCGAGCAACATCCTGATTCCACTAAGCTGGAAACCT
TCTTTAAAATCCTGTCGGCATTGAATTTAGAACTTACTGTTACGCCCAGGAATGTGGACACCACCAATAACGAAGCCTCT
GTTGCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References