Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1807506..1807929 Replicon chromosome
Accession NZ_CP047791
Organism Staphylococcus aureus strain UP_818

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag E3S89_RS09110 Protein ID WP_001065091.1
Coordinates 1807678..1807929 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag E3S89_RS09105 Protein ID WP_000028422.1
Coordinates 1807506..1807688 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S89_RS09060 1802891..1804552 - 1662 WP_000625088.1 terminase large subunit -
E3S89_RS09065 1804549..1804893 - 345 WP_000402904.1 hypothetical protein -
E3S89_RS09070 1805023..1805322 - 300 WP_000988336.1 HNH endonuclease -
E3S89_RS09075 1805554..1805970 - 417 WP_000590122.1 hypothetical protein -
E3S89_RS09080 1805998..1806198 - 201 WP_000265043.1 DUF1514 family protein -
E3S89_RS09085 1806198..1806347 - 150 WP_000595265.1 transcriptional activator RinB -
E3S89_RS09090 1806344..1806709 - 366 WP_001811577.1 hypothetical protein -
E3S89_RS09095 1806728..1806934 - 207 WP_000195803.1 DUF1381 domain-containing protein -
E3S89_RS09100 1806971..1807513 - 543 WP_000185659.1 dUTP pyrophosphatase -
E3S89_RS09105 1807506..1807688 - 183 WP_000028422.1 hypothetical protein Antitoxin
E3S89_RS09110 1807678..1807929 - 252 WP_001065091.1 DUF1024 family protein Toxin
E3S89_RS14525 1807922..1808086 - 165 WP_000990744.1 hypothetical protein -
E3S89_RS09115 1808101..1808343 - 243 WP_000131366.1 hypothetical protein -
E3S89_RS09120 1808347..1808715 - 369 WP_000101274.1 hypothetical protein -
E3S89_RS09125 1808728..1809037 - 310 Protein_1758 RusA family crossover junction endodeoxyribonuclease -
E3S89_RS09130 1809046..1809264 - 219 WP_000338531.1 hypothetical protein -
E3S89_RS09135 1809271..1810144 - 874 Protein_1760 DnaD domain protein -
E3S89_RS09140 1810174..1810644 - 471 WP_000934764.1 single-stranded DNA-binding protein -
E3S89_RS09145 1810645..1811262 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
E3S89_RS09150 1811343..1812263 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL 1774063..1847791 73728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T147761 WP_001065091.1 NZ_CP047791:c1807929-1807678 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T147761 NZ_CP063241:c1021762-1021487 [Pectobacterium brasiliense]
ATACAAACGAACCAGCAAGTAAAAAAGCAGAGTGATATTGTCGACACACCAAAACGACGGATGGTCATTCCGCTTATCGA
AGCACATCACCTGTCTGAGAAAGTGAATAAGAAGTTGTTCCCTCTGATCCGCATTGATGATGGCGAAGATTATCGGCTGA
TGACGACTGAAATATCGAGCGTTCCCGTTGAGGTCATTGGTGAAGTGATTGCAGACCTTGGCGAGTACGCCGATGAGATT
AAGGATGTGATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT147761 WP_000028422.1 NZ_CP047791:c1807688-1807506 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT147761 NZ_CP063241:c1022001-1021783 [Pectobacterium brasiliense]
ATGAAACGCCGGATTAGCATTGCCGTGGACAAAGGTGACTATCAGATTCTGAGTGCTGCCGGAGTTAATATTTCCGAGCT
GGTGAATGACGCCCTTGGCAAAGAAGCCCGCCGCATAAAGACTGAGGCGTGGAAGAAGGAAAACCGCGAAGGGATGGAAA
ACGTCGCCCGATTTATCGCAAAGAATGGTTCTTTTGCGGATGAAAATAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References