Detailed information of TA system TA147758

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1784186..1784493
• Replicon: chromosome
• Accession: NZ_CP047791
• Organism: Staphylococcus aureus strain UP_818

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S89_RS08965
• Protein ID: WP_011447039.1
• Coordinates: 1784317..1784493 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1784186..1784325 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S89_RS08925	1779524..1779784	+	261	WP_001791826.1	hypothetical protein	-
E3S89_RS08930	1779837..1780187	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3S89_RS08935	1780873..1781322	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3S89_RS08940	1781417..1781752	-	336	Protein_1720	SH3 domain-containing protein	-
E3S89_RS08945	1782402..1782893	-	492	WP_000919350.1	staphylokinase	-
E3S89_RS08950	1783084..1783839	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3S89_RS08955	1783851..1784105	-	255	WP_000611512.1	phage holin	-
E3S89_RS08960	1784157..1784264	+	108	WP_001791821.1	hypothetical protein	-
-	1784186..1784325	+	140	NuclAT_0	-	Antitoxin
-	1784186..1784325	+	140	NuclAT_0	-	Antitoxin
-	1784186..1784325	+	140	NuclAT_0	-	Antitoxin
-	1784186..1784325	+	140	NuclAT_0	-	Antitoxin
E3S89_RS08965	1784317..1784493	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3S89_RS08970	1784602..1785375	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
E3S89_RS08975	1785796..1786170	-	375	WP_000340977.1	hypothetical protein	-
E3S89_RS08980	1786226..1786513	-	288	WP_001040259.1	hypothetical protein	-
E3S89_RS08985	1786560..1786712	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL	1774063..1847791	73728

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147758 WP_011447039.1 NZ_CP047791:c1784493-1784317 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147758 NZ_CP063241:c519690-519436 [Pectobacterium brasiliense]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAACCACTTAAACATAACCTCGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT147758 NZ_CP047791:1784186-1784325 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin