Detailed information of TA system TA147751

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20960..21298
• Replicon: chromosome
• Accession: NZ_CP047791
• Organism: Staphylococcus aureus strain UP_818

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S89_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20960..21136 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	21124..21298 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S89_RS00090	18741..18893	+	153	WP_001153681.1	hypothetical protein	-
E3S89_RS00095	18940..19227	+	288	WP_001040259.1	hypothetical protein	-
E3S89_RS00100	19283..19657	+	375	WP_000340977.1	hypothetical protein	-
E3S89_RS00105	20078..20851	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
E3S89_RS00110	20960..21136	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	21124..21298	-	175	-	-	Antitoxin
E3S89_RS00120	21348..21602	+	255	WP_000611512.1	phage holin	-
E3S89_RS00125	21614..22369	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3S89_RS00130	23267..24094	-	828	WP_000136022.1	alpha/beta hydrolase	-
E3S89_RS00135	24152..25366	-	1215	WP_000286469.1	NADH-dependent flavin oxidoreductase	-
E3S89_RS00140	25462..25560	+	99	WP_001803958.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea	1..22369	22368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147751 WP_011447039.1 NZ_CP047791:20960-21136 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147751 NZ_CP063238:c4350667-4350245 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT147751 NZ_CP047791:c21298-21124 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin