Detailed information of TA system TA147745

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2594922..2595184
• Replicon: chromosome
• Accession: NZ_CP047790
• Organism: Staphylococcus aureus strain UP_830

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S90_RS12720
• Protein ID: WP_001802298.1
• Coordinates: 2594922..2595026 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2595021..2595184 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S90_RS12705	2591719..2592501	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
E3S90_RS12710	2592569..2593426	+	858	WP_000370928.1	Cof-type HAD-IIB family hydrolase	-
E3S90_RS12715	2594084..2594242	-	159	WP_001792784.1	hypothetical protein	-
E3S90_RS12720	2594922..2595026	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2595021..2595184	-	164	-	-	Antitoxin
E3S90_RS12725	2595468..2596559	-	1092	WP_000495681.1	hypothetical protein	-
E3S90_RS12730	2596825..2597805	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
E3S90_RS12735	2597807..2598127	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S90_RS12740	2598279..2598944	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147745 WP_001802298.1 NZ_CP047790:2594922-2595026 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147745 NZ_CP063238:c1230932-1230618 [Serratia marcescens]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCGGGGAGTACGCGACCGGAACGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT147745 NZ_CP047790:c2595184-2595021 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin