Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2338777..2339294 Replicon chromosome
Accession NZ_CP047790
Organism Staphylococcus aureus strain UP_830

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3S90_RS11410 Protein ID WP_000113262.1
Coordinates 2339028..2339294 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S90_RS11405 Protein ID WP_000584499.1
Coordinates 2338777..2339028 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S90_RS11375 2334469..2335188 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S90_RS11380 2335185..2335916 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S90_RS11385 2336013..2337263 - 1251 WP_160195055.1 FemA/FemB family glycyltransferase FmhA -
E3S90_RS11390 2337518..2337886 + 369 WP_160195056.1 DUF4467 domain-containing protein -
E3S90_RS11395 2337905..2338504 + 600 WP_000162803.1 DsbA family protein -
E3S90_RS11400 2338511..2338612 + 102 Protein_2201 hypothetical protein -
E3S90_RS11405 2338777..2339028 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S90_RS11410 2339028..2339294 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3S90_RS11415 2339588..2341138 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S90_RS11420 2341324..2341791 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3S90_RS11425 2341878..2342060 + 183 WP_000079142.1 hypothetical protein -
E3S90_RS11430 2342277..2343101 + 825 WP_000572040.1 formate/nitrite transporter family protein -
E3S90_RS11435 2343335..2343871 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T147744 WP_000113262.1 NZ_CP047790:2339028-2339294 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147744 NZ_CP063238:c1116567-1116364 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT147744 WP_000584499.1 NZ_CP047790:2338777-2339028 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT147744 NZ_CP063238:c1116985-1116617 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References