Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2313801..2313985 Replicon chromosome
Accession NZ_CP047790
Organism Staphylococcus aureus strain UP_830

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag E3S90_RS11275 Protein ID WP_000482650.1
Coordinates 2313801..2313908 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2313925..2313985 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S90_RS11250 2309173..2309646 + 474 WP_000456489.1 GyrI-like domain-containing protein -
E3S90_RS11255 2309769..2310980 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
E3S90_RS11260 2311162..2311821 - 660 WP_000831298.1 membrane protein -
E3S90_RS11265 2311881..2313023 - 1143 WP_001176863.1 glycerate kinase -
E3S90_RS11270 2313281..2313667 + 387 WP_000779358.1 flippase GtxA -
E3S90_RS11275 2313801..2313908 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2313925..2313985 - 61 - - Antitoxin
E3S90_RS11280 2314556..2316319 + 1764 WP_001064820.1 ABC transporter ATP-binding protein/permease -
E3S90_RS11285 2316344..2318077 + 1734 WP_160195054.1 ABC transporter ATP-binding protein/permease -
E3S90_RS11290 2318308..2318475 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T147742 WP_000482650.1 NZ_CP047790:2313801-2313908 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T147742 NZ_CP063238:56427-56702 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 61 bp

>AT147742 NZ_CP047790:c2313985-2313925 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References