Detailed information of TA system TA147728

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2647798..2648061
• Replicon: chromosome
• Accession: NZ_CP047789
• Organism: Staphylococcus aureus strain UP_967

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S93_RS13185
• Protein ID: WP_001802298.1
• Coordinates: 2647798..2647902 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2647897..2648061 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S93_RS13160	2643182..2643964	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
E3S93_RS13165	2644032..2644889	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E3S93_RS13170	2645594..2645686	-	93	WP_001790138.1	hypothetical protein	-
E3S93_RS13175	2645975..2647111	+	1137	WP_000115564.1	SAP domain-containing protein	-
E3S93_RS13180	2647154..2647637	+	484	Protein_2548	recombinase family protein	-
E3S93_RS13185	2647798..2647902	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2647897..2648061	-	165	-	-	Antitoxin
E3S93_RS13190	2648402..2649493	-	1092	WP_000495671.1	lytic regulatory protein	-
E3S93_RS13195	2649759..2650739	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E3S93_RS13200	2650741..2651061	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S93_RS13205	2651213..2651878	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147728 WP_001802298.1 NZ_CP047789:2647798-2647902 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147728 NZ_CP063229:c4066877-4066488 [Serratia marcescens]
ATGTATATGTTTGATACCAATACCGTCAGCCACTTGTTTCGACGGCATCCGCAGGTGCTGAGCATAATGGAAAAGCTTCC
GCCTTCCGCCGTGTGCATTTCCAGCGTAACCGAAGCGGAGCTGCTTTACGGCGTGGCTAAACGGCGCAACCAAGCGTTGC
AAAAGGCGGTCGAGGCCTTTCTTTCCGCTGTCACTGTGCAGGCCTGGGATAGTGAGGCAGCCCGTTGCTACGGTGAAATG
CGTGCGAACATGGAGAAAAAGGGAAAAACCATGGGCGCGCTGGATCAACTGATCGCTGCTCATGCGCAGAGCCGTGGCGC
GACGTTGGTGACCAACGATCGCGCTTTCGCCATGGTGCCCGGGTTGGCGGTCGAAGACTGGACGCGCTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT147728 NZ_CP047789:c2648061-2647897 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin