Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2382499..2383016 Replicon chromosome
Accession NZ_CP047789
Organism Staphylococcus aureus strain UP_967

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3S93_RS11805 Protein ID WP_000113262.1
Coordinates 2382750..2383016 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S93_RS11800 Protein ID WP_000584499.1
Coordinates 2382499..2382750 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S93_RS11770 2378197..2378916 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S93_RS11775 2378913..2379644 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S93_RS11780 2379741..2380991 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3S93_RS11785 2381246..2381608 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S93_RS11790 2381627..2382226 + 600 WP_000162813.1 DsbA family protein -
E3S93_RS11795 2382233..2382334 + 102 WP_001791744.1 hypothetical protein -
E3S93_RS11800 2382499..2382750 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S93_RS11805 2382750..2383016 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3S93_RS11810 2383051..2383122 + 72 Protein_2283 hypothetical protein -
E3S93_RS11815 2383311..2384861 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S93_RS11820 2385047..2385514 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3S93_RS11825 2385598..2385780 + 183 WP_000230294.1 hypothetical protein -
E3S93_RS11830 2385997..2386821 + 825 WP_000572040.1 formate/nitrite transporter family protein -
E3S93_RS11835 2387054..2387590 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T147727 WP_000113262.1 NZ_CP047789:2382750-2383016 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147727 NZ_CP063229:c3964577-3964221 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTATACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT147727 WP_000584499.1 NZ_CP047789:2382499-2382750 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT147727 NZ_CP063229:c3964783-3964574 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References