Detailed information of TA system TA147725

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2357480..2357664
• Replicon: chromosome
• Accession: NZ_CP047789
• Organism: Staphylococcus aureus strain UP_967

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: E3S93_RS11670
• Protein ID: WP_000482650.1
• Coordinates: 2357480..2357587 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2357604..2357664 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S93_RS11645	2352842..2353315	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3S93_RS11650	2353438..2354649	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S93_RS11655	2354831..2355490	-	660	WP_000831298.1	membrane protein	-
E3S93_RS11660	2355550..2356692	-	1143	WP_001176863.1	glycerate kinase	-
E3S93_RS11665	2356960..2357346	+	387	WP_000779358.1	flippase GtxA	-
E3S93_RS11670	2357480..2357587	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2357604..2357664	-	61	-	-	Antitoxin
E3S93_RS11675	2358215..2359978	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
E3S93_RS11680	2360003..2361736	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3S93_RS11685	2361967..2362134	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T147725 WP_000482650.1 NZ_CP047789:2357480-2357587 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147725 NZ_CP063229:2098279-2098375 [Serratia marcescens]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin

Nucleotide

• Length: 61 bp

>AT147725 NZ_CP047789:c2357664-2357604 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin