Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2844501..2844924 Replicon chromosome
Accession NZ_CP047788
Organism Staphylococcus aureus strain UP_1033

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag E3S95_RS14070 Protein ID WP_001065091.1
Coordinates 2844501..2844752 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag E3S95_RS14075 Protein ID WP_000028422.1
Coordinates 2844742..2844924 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S95_RS14025 2840156..2841076 + 921 WP_000138472.1 recombinase RecT -
E3S95_RS14030 2841157..2841774 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
E3S95_RS14035 2841775..2842245 + 471 WP_000934764.1 single-stranded DNA-binding protein -
E3S95_RS14040 2842275..2843159 + 885 WP_000148316.1 DnaD domain protein -
E3S95_RS14045 2843166..2843384 + 219 WP_000338531.1 hypothetical protein -
E3S95_RS14050 2843393..2843702 + 310 Protein_2726 RusA family crossover junction endodeoxyribonuclease -
E3S95_RS14055 2843715..2844083 + 369 WP_000101274.1 hypothetical protein -
E3S95_RS14060 2844087..2844329 + 243 WP_000131366.1 hypothetical protein -
E3S95_RS14065 2844335..2844508 + 174 WP_001793974.1 hypothetical protein -
E3S95_RS14070 2844501..2844752 + 252 WP_001065091.1 DUF1024 family protein Toxin
E3S95_RS14075 2844742..2844924 + 183 WP_000028422.1 hypothetical protein Antitoxin
E3S95_RS14080 2844917..2845459 + 543 WP_000185659.1 dUTP pyrophosphatase -
E3S95_RS14085 2845496..2845702 + 207 WP_000195803.1 DUF1381 domain-containing protein -
E3S95_RS14090 2845699..2846085 + 387 WP_000592207.1 hypothetical protein -
E3S95_RS14095 2846082..2846231 + 150 WP_000595265.1 transcriptional activator RinB -
E3S95_RS14100 2846231..2846431 + 201 WP_000265043.1 DUF1514 family protein -
E3S95_RS14105 2846459..2846875 + 417 WP_000590122.1 hypothetical protein -
E3S95_RS14110 2847107..2847406 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / tsst-1 / hlb 2804629..2847406 42777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T147717 WP_001065091.1 NZ_CP047788:2844501-2844752 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T147717 NZ_CP063224:c3862463-3862053 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT147717 WP_000028422.1 NZ_CP047788:2844742-2844924 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT147717 NZ_CP063224:c3862710-3862444 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References