Detailed information of TA system TA147703

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1095108..1095305
• Replicon: chromosome
• Accession: NZ_CP047788
• Organism: Staphylococcus aureus strain UP_1033

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: E3S95_RS05535
• Protein ID: WP_000623369.1
• Coordinates: 1095198..1095305 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1095108..1095145 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S95_RS05500	1090301..1090588	-	288	WP_000410718.1	hypothetical protein	-
E3S95_RS05505	1090929..1091219	+	291	WP_001791476.1	hypothetical protein	-
E3S95_RS05510	1091307..1091948	-	642	WP_000571191.1	ABC transporter ATP-binding protein	-
E3S95_RS05515	1091945..1092265	-	321	WP_000873929.1	YxeA family protein	-
E3S95_RS05520	1092268..1094232	-	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
E3S95_RS05525	1094276..1094548	-	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
E3S95_RS05530	1094558..1094659	-	102	WP_001790623.1	hypothetical protein	-
-	1095108..1095145	+	38	-	-	Antitoxin
E3S95_RS05535	1095198..1095305	-	108	WP_000623369.1	putative holin-like toxin	Toxin
E3S95_RS05540	1095576..1096178	-	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
E3S95_RS05545	1096193..1096369	-	177	WP_000214898.1	YkvS family protein	-
E3S95_RS05550	1096568..1097554	+	987	WP_000668820.1	lipoate--protein ligase	-
E3S95_RS05555	1097635..1097853	-	219	WP_000876825.1	IDEAL domain-containing protein	-
E3S95_RS05560	1098063..1098632	+	570	WP_000287265.1	competence protein ComK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T147703 WP_000623369.1 NZ_CP047788:c1095305-1095198 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T147703 NZ_CP063215:c4687745-4687461 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 38 bp

>AT147703 NZ_CP047788:1095108-1095145 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin