Detailed information of TA system TA147700

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 511333..511912
• Replicon: chromosome
• Accession: NZ_CP047788
• Organism: Staphylococcus aureus strain UP_1033

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3S95_RS02735
• Protein ID: WP_001025401.1
• Coordinates: 511333..511578 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	511547..511912 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S95_RS02690	507583..508197	+	615	WP_000191466.1	hypothetical protein	-
E3S95_RS02695	508194..508340	-	147	WP_001013104.1	hypothetical protein	-
E3S95_RS02700	508377..508559	-	183	WP_000705240.1	hypothetical protein	-
E3S95_RS02705	508629..509360	-	732	WP_000511090.1	XRE family transcriptional regulator	-
E3S95_RS02710	509512..509724	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
E3S95_RS02715	509772..510215	+	444	WP_000435357.1	hypothetical protein	-
E3S95_RS14125	510230..510379	+	150	WP_000771849.1	hypothetical protein	-
E3S95_RS02720	510420..510632	-	213	WP_000362644.1	hypothetical protein	-
E3S95_RS02725	510702..510899	+	198	WP_001148860.1	hypothetical protein	-
E3S95_RS02730	510886..511266	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
E3S95_RS02735	511333..511578	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3S95_RS02740	511547..511912	-	366	WP_001128433.1	hypothetical protein	Antitoxin
E3S95_RS02745	511967..512182	+	216	WP_001097553.1	hypothetical protein	-
E3S95_RS02750	512207..512470	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
E3S95_RS02755	512482..512643	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3S95_RS02760	512722..513045	+	324	WP_000174998.1	hypothetical protein	-
E3S95_RS02765	513060..513422	+	363	WP_000279448.1	hypothetical protein	-
E3S95_RS02770	513419..514585	+	1167	WP_000762531.1	DUF2800 domain-containing protein	-
E3S95_RS02775	514611..515168	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T147700 WP_001025401.1 NZ_CP047788:511333-511578 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147700 NZ_CP063215:c3816218-3815901 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT147700 NZ_CP047788:c511912-511547 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin