Detailed information of TA system TA147694

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20056..20394
• Replicon: chromosome
• Accession: NZ_CP047788
• Organism: Staphylococcus aureus strain UP_1033

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S95_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20056..20232 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20220..20394 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S95_RS00085	17837..17989	+	153	WP_001153681.1	hypothetical protein	-
E3S95_RS00090	18036..18323	+	288	WP_001040259.1	hypothetical protein	-
E3S95_RS00095	18379..18753	+	375	WP_042363643.1	hypothetical protein	-
E3S95_RS00100	19174..19947	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
E3S95_RS00105	20056..20232	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	20220..20394	-	175	-	-	Antitoxin
E3S95_RS00115	20444..20698	+	255	WP_000611512.1	phage holin	-
E3S95_RS00120	20710..21465	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3S95_RS00125	21656..22147	+	492	WP_000919350.1	staphylokinase	-
E3S95_RS00130	22797..23132	+	336	Protein_26	SH3 domain-containing protein	-
E3S95_RS00135	23227..23676	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3S95_RS00140	24362..24712	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3S95_RS00145	24765..25025	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / chp / scn	1..24712	24711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147694 WP_011447039.1 NZ_CP047788:20056-20232 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147694 NZ_CP063214:4636674-4636976 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT147694 NZ_CP047788:c20394-20220 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin