Detailed information of TA system TA147692

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2367754..2367938
• Replicon: chromosome
• Accession: NZ_CP047787
• Organism: Staphylococcus aureus strain UP_1108

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S97_RS11575
• Protein ID: WP_000482647.1
• Coordinates: 2367831..2367938 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2367754..2367814 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S97_RS11555	2363340..2363507	-	168	WP_031785511.1	hypothetical protein	-
E3S97_RS11560	2363738..2365471	-	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3S97_RS11565	2365520..2367259	-	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3S97_RS11570	2367637..2367804	-	168	WP_000301894.1	hypothetical protein	-
-	2367754..2367814	+	61	-	-	Antitoxin
E3S97_RS11575	2367831..2367938	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S97_RS11580	2368072..2368458	-	387	WP_000779354.1	flippase GtxA	-
E3S97_RS11585	2368726..2369868	+	1143	WP_064131576.1	glycerate kinase	-
E3S97_RS11590	2369928..2370587	+	660	WP_000831298.1	membrane protein	-
E3S97_RS11595	2370767..2371978	+	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S97_RS11600	2372101..2372574	-	474	WP_000456491.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147692 WP_000482647.1 NZ_CP047787:c2367938-2367831 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147692 NZ_CP063214:c4310085-4309708 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147692 NZ_CP047787:2367754-2367814 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin